This essay focuses on technical and logistical aspects of the use of spolia in early modern Rome. Quite independently of the artistic, conceptual and political intentions underlying the use of spolia, practical questions also arose, e.g. how a column was to be transported and erected, where craftsmen capable of working with marble were to be found, and what costs were to be expected. Furthermore, this article sheds light on the expertise that gradually developed in dealing with spolia. To this end, an oft-overlooked section of Sebastiano Serlio’s seventh book featuring a highly practical treatment of designing and planning with spolia material is analyzed.